Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2010 Apr;13(4):419-21. doi: 10.1038/nn.2510. Epub 2010 Mar 14.

Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits.

Author information

1
Department of Psychology, Vanderbilt University, Nashville, Tennessee, USA. joshua.buckholtz@vanderbilt.edu

Abstract

Psychopathy is a personality disorder that is strongly linked to criminal behavior. Using [(18)F]fallypride positron emission tomography and blood oxygen level-dependent functional magnetic resonance imaging, we found that impulsive-antisocial psychopathic traits selectively predicted nucleus accumbens dopamine release and reward anticipation-related neural activity in response to pharmacological and monetary reinforcers, respectively. These findings suggest that neurochemical and neurophysiological hyper-reactivity of the dopaminergic reward system may comprise a neural substrate for impulsive-antisocial behavior and substance abuse in psychopathy.

PMID:
20228805
PMCID:
PMC2916168
DOI:
10.1038/nn.2510
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center