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Hum Reprod. 2010 May;25(5):1335-8. doi: 10.1093/humrep/deq058. Epub 2010 Mar 13.

Intermediate sized CGG repeats are not a common cause of idiopathic premature ovarian failure.

Author information

1
Peninsula Medical School, University of Exeter, Exeter EX1 2LU, UK.

Abstract

BACKGROUND:

It is recognized that FMR1 premutation expansions are associated with premature ovarian failure (POF), but the role of smaller repeats at the boundary of premutation and normal is less clear.

METHODS:

We have therefore investigated the incidence of these intermediate sized FMR1 CGG repeats (35-58 repeats) in a series of 366 women ascertained because of menopause before the age of 40.

RESULTS:

We found no significant difference in the incidence of intermediates in cases compared with controls. Thus, we were unable to replicate previous studies showing a positive association, despite a significantly larger sample size.

CONCLUSIONS:

We therefore conclude that intermediate sized FMR1 CGG repeat alleles should not be considered a high-risk factor for POF based on current evidence.

PMID:
20228389
PMCID:
PMC2854048
DOI:
10.1093/humrep/deq058
[Indexed for MEDLINE]
Free PMC Article

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