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J Antimicrob Chemother. 2010 May;65(5):995-8. doi: 10.1093/jac/dkq070. Epub 2010 Mar 12.

Extracellular concentrations of fosfomycin in lung tissue of septic patients.

Author information

1
Division of Thoracic and Hyperbaric Surgery, Medical University of Graz, Graz, Austria.

Abstract

OBJECTIVES:

The present investigation explored the ability of fosfomycin to penetrate lung tissue of septic patients by utilizing the microdialysis technique.

METHODS:

After microdialysis probe insertion into healthy and infected lung tissue, a single intravenous dose of 4 g of fosfomycin was administered.

RESULTS:

The mean C(max), T(max), AUC(0-4) and AUC(0-infinity) for healthy lung were 131.6 +/- 110.6 mg/L, 1.1 +/- 0.4 h, 242.4 +/- 101.6 mgxh/L and 367.6 +/- 111.9 mgxh/L, respectively. The corresponding values for infected lung were 107.5 +/- 60.2 mg/L, 1.4 +/- 0.5 h, 203.5 +/- 118.4 mgxh/L and 315.1 +/- 151.2 mgxh/L. The half-life of fosfomycin ranged from 2.2 to 2.7 h between compartments. The magnitude of lung tissue penetration, as determined by the ratios of the AUC(0-infinity) for lung to the AUC(0-infinity) for plasma, was 0.63 +/- 0.31 and 0.53 +/- 0.31 for healthy and infected lung, respectively.

CONCLUSIONS:

We conclude that fosfomycin achieves antimicrobially effective concentrations in infected lung tissue.

PMID:
20228081
DOI:
10.1093/jac/dkq070
[Indexed for MEDLINE]

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