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J Pediatr. 2010 Jun;156(6):960-964.e2. doi: 10.1016/j.jpeds.2009.12.023. Epub 2010 Mar 15.

Maternal zinc supplementation reduces diarrheal morbidity in peruvian infants.

Author information

1
Institute of Public Health, George Warren Brown School of Social Work, St. Louis, MO.
2
Instituto de InvestigaciĆ³n Nutricional, Lima, Peru.
3
Department of Nutrition, Harvard School of Public Health, Boston, MA.
4
Center for Human Nutrition, Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address: lcaulfie@jhsph.edu.

Abstract

OBJECTIVE:

To test whether zinc supplementation during pregnancy would reduce infant morbidity rates.

STUDY DESIGN:

A double-blind, randomized controlled trial of prenatal zinc supplementation was conducted from 1995 to 1997 in a periurban slum of Lima, Peru. Participants were randomly assigned to receive daily supplementation with zinc (15 mg zinc + 60 mg iron + 250 microg folic acid) or placebo (60 iron + 250 microg folic acid) from 10 to 24 weeks gestation until 1 month postpartum. Anthropometry was measured monthly from birth through age 12 months, and morbidity and dietary intake were measured weekly from 6 to 12 months (n = 421).

RESULTS:

The average percentage of observation days with diarrhea among infants prenatally treated with zinc (5.8%) was reduced compared with infants in the control group (7.7%) (P = .01). Prenatal zinc supplementation reduced the likelihood of an infant experiencing diarrheal episodes of acute diarrhea lasting longer than 7 days (OR 0.66, 95% CI 0.43, 0.99, P = .04) and mucus in the stool (OR 0.65 95% CI 0.46, 0.92, P = .01) adjusting for infant age, breastfeeding, season, and hygiene and sanitation covariates. No treatment effects on respiratory illnesses, fever, or skin conditions were detected.

CONCLUSIONS:

Improving prenatal zinc nutrition protected against diarrheal morbidity in infant offspring through 12 months of age.

PMID:
20227716
DOI:
10.1016/j.jpeds.2009.12.023
[Indexed for MEDLINE]

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