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Biochem Biophys Res Commun. 2010 Apr 16;394(4):884-9. doi: 10.1016/j.bbrc.2010.03.020. Epub 2010 Mar 20.

Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation.

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CNRS, UMR 6061 Institut de Génétique et Développement de Rennes, Expression Génétique et Développement, Université de Rennes I, IFR 140 GFAS, 2 avenue du Professeur Léon Bernard, CS 34317, 35043 Rennes Cedex, France.


CUGBP1 is an RNA-binding protein controlling alternative splicing, mRNA translation and stability. In this work we used a motif scoring approach to identify putative CUGBP1 binding sites for genes located on the human chromosome 12. This allowed us to identify the gene CD9 as a presumptive target for CUGBP1-mediated regulation. In a number of cancers, the tetraspanin CD9 is down-regulated, an event correlated with a bad prognostic. Using a combination of biochemical approaches and CUGBP1 knockdown, we showed that CUGBP1 directly controls CD9 expression.

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