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Am J Obstet Gynecol. 2010 Jul;203(1):70.e1-8. doi: 10.1016/j.ajog.2010.01.062. Epub 2010 Mar 12.

A systematic literature review of vitamin D and ovarian cancer.

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1
Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.

Abstract

OBJECTIVE:

We assessed the evidence supporting a reduction in risk for ovarian cancer occurrence or mortality with greater vitamin D exposures.

STUDY DESIGN:

This review followed standard guidelines for systematic literature reviews. The diverse study designs precluded a quantitative metaanalysis. Therefore studies are summarized via tables and abstracted information.

RESULTS:

Approximately half of the ecologic and case-control studies reported reductions in incidence or mortality with increasing geographic latitude, solar radiation levels, or dietary/supplement consumption of vitamin D, whereas the other half reported null associations. The cohort studies reported no overall risk reduction with increasing dietary/supplement consumption of vitamin D or with plasma levels of vitamin D prior to diagnosis, although vitamin D intakes were relatively low in all studies.

CONCLUSION:

There is no consistent or strong evidence to support the claim made in numerous review articles that vitamin D exposures reduce the risk for ovarian cancer occurrence or mortality.

PMID:
20227054
DOI:
10.1016/j.ajog.2010.01.062
[Indexed for MEDLINE]
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