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Cancer Cell. 2010 Mar 16;17(3):215-6. doi: 10.1016/j.ccr.2010.02.024.

IDH1 and IDH2: not your typical oncogenes.

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The Preston Robert Tisch Brain Tumor Center at Duke, The Pediatric Brain Tumor Institute, and The Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.


Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations.

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