Format

Send to

Choose Destination
Trends Pharmacol Sci. 2010 May;31(5):212-20. doi: 10.1016/j.tips.2010.02.003. Epub 2010 Mar 11.

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.

Author information

1
Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Abstract

Since the discovery of NAD-dependent deacetylase activity of the silent information regulator-2 (SIR2) family ('sirtuins'), many exciting connections between protein deacetylation and energy metabolism have been revealed. The importance of sirtuins in the regulation of many fundamental biological responses to various nutritional and environmental stimuli has been firmly established. Sirtuins have also emerged as critical regulators for aging and longevity in model organisms. Their absolute requirement of NAD has revived an enthusiasm in the study of mammalian biosynthesis of NAD. Sirtuin-targeted pharmaceutical and nutriceutical interventions against age-associated diseases are also on the horizon. This review summarizes the recent progress in sirtuin research (particularly in mammalian sirtuin biology) and re-evaluates the connection between sirtuins, metabolism, and age-associated diseases (e.g., type-2 diabetes) to set a basis for the next ten years of sirtuin research.

PMID:
20226541
PMCID:
PMC3526941
DOI:
10.1016/j.tips.2010.02.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center