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Nat Rev Immunol. 2010 Apr;10(4):236-47. doi: 10.1038/nri2729. Epub 2010 Mar 12.

Effector and regulatory B cells: modulators of CD4+ T cell immunity.

Author information

1
Department of Medicine, University of Rochester Medical Center, New York 14642, USA. frances_lund@urmc.rochester.edu

Abstract

B cells are essential for humoral immunity, but the role that they have in regulating CD4(+) T cell responses remains controversial. However, new data showing that the transient depletion of B cells potently influences the induction, maintenance and reactivation of CD4(+) T cells, with the recent identification of antibody-independent functions of B cells, have reinvigorated interest in the many roles of B cells in both infectious and autoimmune diseases. In this Review, we discuss recent data showing how effector and regulatory B cells modulate CD4(+) T cell responses to pathogens and autoantigens.

PMID:
20224569
PMCID:
PMC3038334
DOI:
10.1038/nri2729
[Indexed for MEDLINE]
Free PMC Article

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