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Trends Endocrinol Metab. 2010 Jun;21(6):345-52. doi: 10.1016/j.tem.2010.01.009. Epub 2010 Mar 10.

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.

Author information

1
Department of Internal Medicine, University of Texas Southwestern Medical Center, Touchstone Center for Diabetes Research, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Roger.Unger@utsouthwestern.edu

Abstract

Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.

PMID:
20223680
PMCID:
PMC2880185
DOI:
10.1016/j.tem.2010.01.009
[Indexed for MEDLINE]
Free PMC Article

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