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Int J Cardiol. 2010 Nov 19;145(2):358-359. doi: 10.1016/j.ijcard.2010.02.034. Epub 2010 Mar 11.

Mechanisms underlying the hypertensive response induced by capsaicin.

Author information

1
Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.
2
Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India. Electronic address: desh48@yahoo.com.

Abstract

Acute ingestion of large quantity of chili peppers (rich source of capsaicin) produced hypertensive crisis in a patient. The hypertensive response was explained on the basis of decreased vasodilator substance calcitonin gene-related peptide (CGRP) from sensory nerve terminals by capsaicin. Here we present our experimental observations in anaesthetized rats regarding the mechanisms underlying hypertensive response induced by capsaicin. Our results demonstrate non-involvement of adrenergic and angiotensinergic mechanisms and also the cardiac changes in producing the response. Thus, the direct action of capsaicin on vascular smooth muscle or the activation of endothelin is proposed.

PMID:
20223533
DOI:
10.1016/j.ijcard.2010.02.034
[Indexed for MEDLINE]

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