Format

Send to

Choose Destination
Neuron. 2010 Mar 11;65(5):682-94. doi: 10.1016/j.neuron.2010.02.015.

Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence.

Author information

1
Ernest Gallo Clinic and Research Center, University of California, San Francisco, San Francisco, CA 94608, USA. woody@gallo.ucsf.edu

Abstract

The cellular mechanisms underlying pathological alcohol seeking remain poorly understood. Here, we show an enhancement of nucleus accumbens (NAcb) core action potential firing ex vivo after protracted abstinence from alcohol but not sucrose self-administration. Increased firing is associated with reduced small-conductance calcium-activated potassium channel (SK) currents and decreased SK3 but not SK2 subunit protein expression. Furthermore, SK activation ex vivo produces greater firing suppression in NAcb core neurons from alcohol- versus sucrose-abstinent rats. Accordingly, SK activation in the NAcb core significantly reduces alcohol but not sucrose seeking after abstinence. In contrast, NAcb shell and lateral dorsal striatal firing ex vivo are not altered after abstinence from alcohol, and SK activation in these regions has little effect on alcohol seeking. Thus, decreased NAcb core SK currents and increased excitability represents a critical mechanism that facilitates motivation to seek alcohol after abstinence.

PMID:
20223203
PMCID:
PMC2847608
DOI:
10.1016/j.neuron.2010.02.015
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center