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Expert Rev Cardiovasc Ther. 2010 Mar;8(3):393-406. doi: 10.1586/erc.10.15.

Type 2 diabetes in children and adolescents.

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The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, Ontario, Canada.


The emergence of Type 2 diabetes (T2D) in children and adolescents parallels the rising rates of childhood obesity. As a condition of impaired insulin sensitivity and relative insulin deficiency resulting in hyperglycemia, T2D has a complex underlying physiology that is reflected by the multiple approaches used to optimize medical care and prevent the myriad of diabetes-related complications. T2D diagnosed in children and adolescents represents a distinct and challenging condition to evaluate and treat. Here, we highlight the epidemiology, pathophysiology, risk factors, clinical presentation and diagnosis, treatment and public health impact of T2D in children and adolescents.

[Indexed for MEDLINE]

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