Abstract
New rugulosins B (2) and C (3) were isolated together with known rugulosin (renamed rugulosin A in this paper, 1) from whole culture of Penicillium radicum FKI-3765-2, and their structures were elucidated by NMR spectroscopy. Rugulosins A and C were a homodimer of the same anthraquinone moieties, whereas rugulosin B was a heterodimer of analogous anthraquinone moieties. Rugulosins A to C showed antimicrobial activity against methicillin-resistant Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / pharmacology
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Methicillin Resistance / drug effects
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Microbial Sensitivity Tests
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Molecular Conformation
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Penicillium / chemistry
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Penicillium / metabolism*
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Staphylococcus aureus / drug effects
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Stereoisomerism
Substances
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Anthraquinones
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Anti-Bacterial Agents
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rugulosin B
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rugulosin C
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rugulosin A