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Fertil Steril. 1991 May;55(5):882-4.

Increased circulating levels of bromocriptine after vaginal compared with oral administration.

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1
Department of Obstetrics and Gynecology, University of Maryland, Baltimore 21201.

Abstract

OBJECTIVE:

To compare the circulating levels of bromocriptine after oral and vaginal administration of the drug.

DESIGN:

Experimental

PARTICIPANTS:

Seven ovulatory female volunteers and one hyperprolactinemic patient.

INTERVENTIONS:

Ovulatory volunteers were randomized to receive either oral or vaginal bromocriptine (2.5 mg). In a second session, the subjects were crossed-over to bromocriptine by the alternate route. An additional hyperprolactinemic patient received vaginal bromocriptine only.

MAIN OUTCOME MEASURE:

Serum bromocriptine and prolactin (PRL) levels were measured hourly for 12 hours in the normal volunteers and for 10 hours in the hyperprolactinemic patient.

RESULTS:

Circulating bromocriptine levels were significantly higher after vaginal bromocriptine after the 7th hour (P less than 0.05). The reduction in serum PRL was significantly greater after oral administration between 2 and 6 hours.

CONCLUSIONS:

Vaginally administered bromocriptine may result in a reduction in the overall dose required, thereby improving compliance without compromising therapeutic efficacy.

PMID:
2022266
[Indexed for MEDLINE]
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