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IUBMB Life. 2010 May;62(5):347-56. doi: 10.1002/iub.319.

Mammalian ceramide synthases.

Author information

1
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.

Abstract

In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and their structure and intracellular localization. Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases.

PMID:
20222015
PMCID:
PMC2858252
DOI:
10.1002/iub.319
[Indexed for MEDLINE]
Free PMC Article

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