Format

Send to

Choose Destination
Pharm Res. 2010 May;27(5):739-49. doi: 10.1007/s11095-010-0065-2. Epub 2010 Mar 11.

In-silico approaches to multi-target drug discovery : computer aided multi-target drug design, multi-target virtual screening.

Author information

1
Bioinformatics and Drug Design Group, Department of Pharmacy, Centre for Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, Singapore, 117543, Singapore.

Abstract

Multi-target drugs against selective multiple targets improve therapeutic efficacy, safety and resistance profiles by collective regulations of a primary therapeutic target together with compensatory elements and resistance activities. Efforts have been made to employ in-silico methods for facilitating the search and design of selective multi-target agents. These methods have shown promising potential in facilitating drug discovery directed at selective multiple targets.

PMID:
20221898
DOI:
10.1007/s11095-010-0065-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center