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Brain Struct Funct. 2010 May;214(4):339-53. doi: 10.1007/s00429-010-0247-z. Epub 2010 Mar 12.

Cytoarchitectonic and chemoarchitectonic characterization of the prefrontal cortical areas in the mouse.

Author information

1
Department of Anatomy and Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

Abstract

This study describes cytoarchitectonic criteria to define the prefrontal cortical areas in the mouse brain (C57BL/6 strain). Currently, well-illustrated mouse brain stereotaxic atlases are available, which, however, do not provide a description of the distinctive cytoarchitectonic characteristics of individual prefrontal areas. Such a description is of importance for stereological, neuronal tracing, and physiological, molecular and neuroimaging studies in which a precise parcellation of the prefrontal cortex (PFC) is required. The present study describes and illustrates: the medial prefrontal areas, i.e., the infralimbic, prelimbic, dorsal and ventral anterior cingulate and Fr2 area; areas of the lateral PFC, i.e., the dorsal agranular insular cortical areas and areas of the ventral PFC, i.e., the lateral, ventrolateral, ventral and medial orbital areas. Each cytoarchitectonically defined boundary is corroborated by one or more chemoarchitectonic stainings, i.e., acetylcholine esterase, SMI32, SMI311, dopamine, parvalbumin, calbindin and myelin staining.

PMID:
20221886
PMCID:
PMC2862954
DOI:
10.1007/s00429-010-0247-z
[Indexed for MEDLINE]
Free PMC Article

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