ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity

Geeta Datta; Manjula Chaddha; Shaila P Handattu; Mayakonda N Palgunachari; Gaurav Nayyar; David W Garber; Himanshu Gupta; C Roger White; G M Anantharamaiah

doi:10.1007/978-1-60761-350-3_1

ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity

Adv Exp Med Biol. 2010:660:1-4. doi: 10.1007/978-1-60761-350-3_1.

Authors

Geeta Datta¹, Manjula Chaddha, Shaila P Handattu, Mayakonda N Palgunachari, Gaurav Nayyar, David W Garber, Himanshu Gupta, C Roger White, G M Anantharamaiah

Affiliation

¹ Departments of Medicine, Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. gdatta@uab.edu

PMID: 20221865
DOI: 10.1007/978-1-60761-350-3_1

Abstract

ApoE mimetic peptide possesses the putative receptor binding domain 141-150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties.

MeSH terms

Animals
Anti-Inflammatory Agents / pharmacology
Apolipoproteins E / chemistry*
Aryldialkylphosphatase / chemistry*
Atherosclerosis / prevention & control
Cell Line
Humans
Hydrogen Peroxide / chemistry*
Lipids / chemistry*
Lipoproteins, HDL / chemistry*
Mice
Peptides / chemistry
Rabbits
Time Factors

Substances

Anti-Inflammatory Agents
Apolipoproteins E
Lipids
Lipoproteins, HDL
Peptides
Hydrogen Peroxide
Aryldialkylphosphatase

Abstract

MeSH terms

Substances

Grants and funding