Format

Send to

Choose Destination
See comment in PubMed Commons below
Nature. 2010 Mar 11;464(7286):287-91. doi: 10.1038/nature08799.

Systematic genetic analysis of muscle morphogenesis and function in Drosophila.

Author information

1
Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. schnorrer@biochem.mpg.de

Abstract

Systematic genetic approaches have provided deep insight into the molecular and cellular mechanisms that operate in simple unicellular organisms. For multicellular organisms, however, the pleiotropy of gene function has largely restricted such approaches to the study of early embryogenesis. With the availability of genome-wide transgenic RNA interference (RNAi) libraries in Drosophila, it is now possible to perform a systematic genetic dissection of any cell or tissue type at any stage of the lifespan. Here we apply these methods to define the genetic basis for formation and function of the Drosophila muscle. We identify a role in muscle for 2,785 genes, many of which we assign to specific functions in the organization of muscles, myofibrils or sarcomeres. Many of these genes are phylogenetically conserved, including genes implicated in mammalian sarcomere organization and human muscle diseases.

PMID:
20220848
DOI:
10.1038/nature08799
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center