In diabetic dogs, many concurrent diseases can cause resistance to exogenous insulin. The most common concurrent disorders in diabetic dogs are hyperadrenocorticism, urinary tract infection, acute pancreatitis, neoplasia, and hypothyroidism. When a concurrent disorder is treated, the insulin dose should be decreased to avoid possible hypoglycemia when an underlying cause of insulin resistance is removed. Hormonal disturbances have been observed in obese dogs, but the clinical significance of these changes is not known.
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