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Adv Exp Med Biol. 2010;654:281-304. doi: 10.1007/978-90-481-3271-3_13.

Cyclic AMP signaling in pancreatic islets.

Author information

1
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4ONR, Scotland, UK. b.l.furman@strath.ac.uk

Abstract

Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet beta-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet beta-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet beta-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the beta-cell.

PMID:
20217503
DOI:
10.1007/978-90-481-3271-3_13
[Indexed for MEDLINE]
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