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Nat Rev Mol Cell Biol. 2010 Apr;11(4):252-63. doi: 10.1038/nrm2868. Epub 2010 Mar 10.

MicroRNA control of signal transduction.

Author information

1
Department of Histology, Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35100 Padua, Italy.

Abstract

MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene expression. After the identification of hundreds of miRNAs, the challenge is now to understand their specific biological function. Signalling pathways are ideal candidates for miRNA-mediated regulation owing to the sharp dose-sensitive nature of their effects. Indeed, emerging evidence suggests that miRNAs affect the responsiveness of cells to signalling molecules such as transforming growth factor-beta, WNT, Notch and epidermal growth factor. As such, miRNAs serve as nodes of signalling networks that ensure homeostasis and regulate cancer, metastasis, fibrosis and stem cell biology.

PMID:
20216554
DOI:
10.1038/nrm2868
[Indexed for MEDLINE]

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