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Diabetes Care. 2010 Jun;33(6):1297-9. doi: 10.2337/dc09-1971. Epub 2010 Mar 9.

Variation of interstitial glucose measurements assessed by continuous glucose monitors in healthy, nondiabetic individuals.

Abstract

OBJECTIVE:

To characterize glucose levels during daily living using continuous glucose monitors (CGMs) in nondiabetic individuals.

RESEARCH DESIGN AND METHODS:

Seventy-four healthy children, adolescents, and adults aged 9-65 years with normal glucose tolerance used a blinded CGM device for 3 to 7 days.

RESULTS:

Sensor glucose concentrations were 71-120 mg/dl for 91% of the day. Sensor values were <or=60 or >140 mg/dl for only 0.2% and 0.4% of the day, respectively. Sensor glucose concentrations were slightly higher in children than adults (P = 0.009) and were slightly lower during the night than day (95 vs. 99 mg/dl, P < 0.001).

CONCLUSIONS:

Glucose values <or=60 and >140 mg/dl, measured with CGM, are uncommon in healthy, nondiabetic individuals. CGM may be useful to evaluate glucose tolerance in nondiabetic individuals over time. Furthermore, these data provide a basis for comparison for studies that use CGM to assess glucose control in subjects with diabetes.

PMID:
20215454
PMCID:
PMC2875442
DOI:
10.2337/dc09-1971
[Indexed for MEDLINE]
Free PMC Article

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