Format

Send to

Choose Destination
J Clin Endocrinol Metab. 2010 May;95(5):2155-62. doi: 10.1210/jc.2009-0659. Epub 2010 Mar 9.

Amount of bone loss in relation to time around the final menstrual period and follicle-stimulating hormone staging of the transmenopause.

Author information

1
Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory Street, Ann Arbor, Michigan 48109, USA. mfsowers@umich.edu

Abstract

BACKGROUND AND OBJECTIVE:

The objective of the study was to describe bone loss rates across the transmenopause related to FSH staging and the final menstrual period (FMP).

DESIGN AND SETTING:

This was a population-based cohort of 629 women (baseline age 24-44 yr) with annual data points over 15 yr.

MEASUREMENTS:

Measures were bone mineral density (BMD), FSH to define four FSH stages, and menstrual bleeding cessation to define the FMP. Bone loss rates were reported by obesity status.

RESULTS:

Annualized rates of lumbar spine bone loss began in FSH stage 3, which occurs approximately 2 yr prior to the FMP (1.67%/yr); bone loss continued into FSH stage 4 (1.21%/yr). Mean spine BMD in FSH stage 4 was 6.4% less than spine BMD value in FSH stage 1. Annualized rates of femoral neck (FN) bone loss began in FSH stage 3 (0.55%/yr) and continued into FSH stage 4 (0.72%/yr). The FN difference between mean values in FSH stage 1 and FSH stage 4 was 5%. Annualized rates of spine bone loss in the 2 yr prior to the FMP were 1.7%/yr, 3.3%/yr in the 2 yr after the FMP, and 1.1%/yr in the 2- to 7-yr period after the FMP. Nonobese women had lower BMD levels and greater bone loss rates.

CONCLUSIONS:

Spine and FN bone loss accelerates in FSH stage 3. Bone loss also began to accelerate 2 yr before the FMP with the greatest loss occurring in the 2 yr after the FMP. Bone loss rates in both spine and FN BMD were greater in nonobese women than obese women.

PMID:
20215399
PMCID:
PMC2869543
DOI:
10.1210/jc.2009-0659
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center