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Nat Rev Genet. 2010 Apr;11(4):259-72. doi: 10.1038/nrg2764.

Gene--environment-wide association studies: emerging approaches.

Author information

1
Medicine, University of Southern California, 1540 Alcazar Street, CHP‑220, Los Angeles, California 90089‑9011, USA. dthomas@usc.edu

Abstract

Despite the yield of recent genome-wide association (GWA) studies, the identified variants explain only a small proportion of the heritability of most complex diseases. This unexplained heritability could be partly due to gene--environment (G×E) interactions or more complex pathways involving multiple genes and exposures. This Review provides a tutorial on the available epidemiological designs and statistical analysis approaches for studying specific G×E interactions and choosing the most appropriate methods. I discuss the approaches that are being developed for studying entire pathways and available techniques for mining interactions in GWA data. I also explore methods for marrying hypothesis-driven pathway-based approaches with 'agnostic' GWA studies.

PMID:
20212493
PMCID:
PMC2891422
DOI:
10.1038/nrg2764
[Indexed for MEDLINE]
Free PMC Article

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