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Curr HIV Res. 2010 Jan;8(1):73-80.

Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV.

Author information

1
Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA. jelder@scripps.edu

Abstract

FIV is a significant pathogen in the cat and is, in addition, the smallest available natural model for the study of lentivirus infections. Although divergent at the amino acid level, the cat lentivirus has an abundance of structural and pathophysiological commonalities with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man. The following review highlights both the strengths and shortcomings of the FIV/cat model, particular as regards development of antiviral drugs.

PMID:
20210782
PMCID:
PMC2853889
[Indexed for MEDLINE]
Free PMC Article

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