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Curr Pharm Biotechnol. 2010 Feb;11(2):223-8.

Enhanced fluorescence of curcumin on plasmonic platforms.

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1
Dept. of Molecular Biology & Immunology and Institute of the Cancer Research, UNTHSC, Fort Worth, TX 76107, USA.

Abstract

We report a significant increase of a curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) fluorescence brightness when deposited on plasmonic platforms (self assembled silver nanostructures formed on the surface of silver semitransparent film). The enhancement of fluorescence intensity is accompanied by a strong decrease in fluorescence lifetime. Simultaneously, the increased photostability of curcumin, a pigment showing strong anti-inflammatory, antioxidant and antitumorigenic activity, allows long-time detection and monitoring. We believe that the use of plasmonic platforms will improve detection, delivery and imaging of curcumin.

PMID:
20210735
[Indexed for MEDLINE]
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