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Clin Infect Dis. 2010 Apr 15;50(8):1174-83. doi: 10.1086/651418.

Cellular CD4 T cell responses to the diphtheria-derived carrier protein of conjugated pneumococcal vaccine and antibody response to pneumococcal vaccination in HIV-infected adults.

Collaborators (137)

Lesprit P, Levy Y, Chêne G, Sarrazin N, Pedrono G, Rabian C, Bursachi P, Commoy MJ, Delfraissy JF, Denis F, Fritzell B, Goujard C, Salamon R, Tubiana R, Viard JP, Krivitzky A, Bentata M, Makki S, Mansouri R, Guillevin L, Jarousse B, Klutse AK, Obenga G, Honoré-Berlureau P, Baazia Y, Soreda S, Clauvel JP, Oksenhendler E, Gerard L, Delgado J, Molina JM, Colin de Verdière N, Palmer P, Madelaine I, Dupon M, Ragnaud JM, Neau D, Raymond I, Garrigue I, Dupin JP, Boitard Ch, Viard JP, El Marsafy S, Lahoulou R, Mogenet A, Broissand C, Delfraissy JF, Delfraissy C, Pereti D, Quertainmont Y, Robquin P, Segeral O, Poirier S, Rannou MT, Idri N, Le Tiec C, Sicard D, Salmon D, Launay O, Silbermann B, Desaint C, Krivine A, Guérin C, Sobel A, Lévy Y, Lesprit P, Lascaux AS, Chesnel Ch, Jung C, Miladi A, Antoine C, Bricaire F, Katlama Ch, Boubezari I, Pierre-François S, Schneider L, Seulié C, Fievet MH, Girard PM, Béglé AM, Besse F, Mouchotte R, Charrois A, Duaguenel-Nguyen A, Yeni P, Fournier I, Lariven S, Phung B, Ralaïmazava P, Gaudebout Ch, Gerbe J, Descamps D, LePoole S, Reynes J, André P, Baillat V, Le Moing V, Merle C, Vidal M, Fondère JM, Roch-Torreilles I, Raffi F, Morineau P, Allavena C, Bonnet B, Hue H, Guarnier E, Lepelletier A, Perré P, Aubry O, Leautez S, Leroy C, Suaud I, Poirier AS, Lepelletier A, Dellamonica P, Rahelinirina V, Sereni MA, Benhamou S, Rigault MC, Massip P, Marchou B, Alvarez M, Bonnet E, Cuzin L, Obadia M, Balsarin F, Barone M, Heraud M, Peyranne I, Mentré F, Morlat P, Chêne G, Sarrazin N, Pedrono G, Tschöpe I, Palmer G.

Author information

1
Laboratoire d'Immunologie et d'Histocompatibilité, St. Louis Hospital, Paris, France.

Abstract

BACKGROUND:

The French National Agency for AIDS and Viral Hepatitis Research (ANRS) 114 Pneumovac trial showed that a strategy combining a 7-valent pneumococcal conjugate vaccine (PCV) prime at week 0 followed by a 23-valent pneumococcal polysaccharide vaccine (PPV) boost at week 4 enhances the frequency and magnitude of immunoglobulin (Ig) G responses against Streptococcus pneumoniae polysaccharides (SPPs) compared with PPV alone. CD4 T cell responses specific to the diphtheria-derived carrier protein CRM(197) were evaluated.

METHODS:

Lymphocyte proliferative responses (LPRs) and T(H)1 cytokine T cell responses against the diphtheria-derived carrier protein CRM(197) contained in the PCV were investigated at weeks 0, 4, and 24.

RESULTS:

In the prime-boost PCV and PPV group, the magnitude of LPRs to diphtheria toxoid and CRM(197) increased at week 4 (P < .001) and persisted until week 24 (P = .08 and .13, respectively, compared with week 4). Interferon-gamma and interleukin-2 production to CRM(197) increased significantly at week 4 (P = .02 and P < .001, respectively) and remained stable until week 24 (P = .28 and P = .08, respectively). No changes were detected in the PPV group. A strong association among the magnitude of LPRs to CRM(197) at week 4, the breadth of SPP specific IgG responses at week 8 (P = .03), and sustained IgG responses at week 24 was observed. A high frequency of helper follicular CD4(+)CXCR5(+) T cells at baseline was associated with a better LPR response to CRM(197.)

CONCLUSIONS:

The PCV prime-elicited memory T cell responses were associated with better and sustained humoral SPP specific IgG responses. ClinicalTrials.gov identifier. NCT00148824.

PMID:
20210645
DOI:
10.1086/651418
[Indexed for MEDLINE]

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