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Int J Eat Disord. 2011 Apr;44(3):262-8. doi: 10.1002/eat.20798.

Sodium oxybate in the treatment of binge eating disorder: an open-label, prospective study.

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1
Research Institute, Lindner Center of HOPE, Mason, Ohio, USA.

Abstract

OBJECTIVE:

To assess preliminarily the effectiveness of sodium oxybate in binge eating disorder.

METHOD:

This was an open-label, prospective, 16-week, flexible dose study of sodium oxybate in binge eating disorder. The primary outcome was binge eating episode frequency.

RESULTS:

Twelve individuals received sodium oxybate, 10 completed at least one postbaseline evaluation, and five completed the study. Mean dose at endpoint was 7.1 (2.0) g/day. Sodium oxybate was associated with significant reductions in frequency of binge days and binge episodes, as well as measures of clinical severity, eating pathology, obsessive-compulsive symptoms, food cravings, body mass index, and body weight. Nine participants had remission of binge eating and five lost ≥5% of their baseline weight; all five of the latter participants had remission of binge eating.

DISCUSSION:

In this open-label trial, sodium oxybate was effective in binge eating disorder, but associated with high a discontinuation rate.

PMID:
20209489
DOI:
10.1002/eat.20798
[Indexed for MEDLINE]

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