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PLoS One. 2010 Mar 1;5(3):e9464. doi: 10.1371/journal.pone.0009464.

Cardiac muscarinic receptor overexpression in sudden infant death syndrome.

Author information

1
Laboratoire de Neurobiologie et Pharmacologie Cardiovasculaire, Université de Strasbourg, Strasbourg, France.

Abstract

BACKGROUND:

Sudden infant death syndrome (SIDS) remains the leading cause of death among infants less than 1 year of age. Disturbed expression of some neurotransmitters and their receptors has been shown in the central nervous system of SIDS victims but no biological abnormality of the peripheral vago-cardiac system has been demonstrated to date. The present study aimed to seek vago-cardiac abnormalities in SIDS victims. The cardiac level of expression of muscarinic receptors, as well as acetylcholinesterase enzyme activity were investigated.

METHODOLOGY/PRINCIPAL FINDINGS:

Left ventricular samples and blood samples were obtained from autopsies of SIDS and children deceased from non cardiac causes. Binding experiments performed with [(3)H]NMS, a selective muscarinic ligand, in cardiac membrane preparations showed that the density of cardiac muscarinic receptors was increased as shown by a more than doubled B(max) value in SIDS (n = 9 SIDS versus 8 controls). On average, the erythrocyte acetylcholinesterase enzyme activity was also significantly increased (n = 9 SIDS versus 11 controls).

CONCLUSIONS:

In the present study, it has been shown for the first time that cardiac muscarinic receptor overexpression is associated with SIDS. The increase of acetylcholinesterase enzyme activity appears as a possible regulatory mechanism.

PMID:
20209124
PMCID:
PMC2830885
DOI:
10.1371/journal.pone.0009464
[Indexed for MEDLINE]
Free PMC Article

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