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Nat Immunol. 2010 Apr;11(4):328-34. doi: 10.1038/ni.1854. Epub 2010 Mar 7.

Regulation of leukocyte recruitment by the long pentraxin PTX3.

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1
Laboratory for Immunology and Inflammation, Instituto di Ricovero e Cura a Carattere Scientifico-Istituto Clinico Humanitas, Rozzano, Italy.

Abstract

Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.

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PMID:
20208538
DOI:
10.1038/ni.1854
[Indexed for MEDLINE]
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