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J Int Assoc Physicians AIDS Care (Chic). 2010 Mar-Apr;9(2):98-103. doi: 10.1177/1545109710361383. Epub 2010 Mar 5.

Indicators of adherence to antiretroviral therapy treatment among HIV/AIDS patients in 5 African countries.

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Institute of Human Virology of the University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.


As the HIV epidemic threatens the social fabric of countries struggling with HIV prevalence rates as high as 10% to 30%, access to antiretroviral therapy (ART) alone is only the beginning of the clinical challenge. There is a need to identify adherence indicators that will ensure long-term treatment success. A cross-sectional review of 921 adult patients on ART for at least 1 year was conducted. Through an administered adherence survey, key indicators were found to be highly correlated with patient adherence. The adherence rate in this sample was 72% after being on treatment for an average of 15 months. This data suggest that having a high perceived quality of care and owning one's own home positively affected patients' adherence. Indicators such as alcohol use in the last month and a high level of depression negatively affected patients' adherence. Targeting specific indicators for specific interventions will guard against nonadherence, leading to treatment failure.

[Indexed for MEDLINE]

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