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Am J Obstet Gynecol. 2010 Mar;202(3):239.e1-239.e10. doi: 10.1016/j.ajog.2010.01.050.

An international trial of antioxidants in the prevention of preeclampsia (INTAPP).

Author information

1
Department of Obstetrics and Gynecology, Hôpital Ste-Justine, Université de Montréal, Montreal, QC, Canada.

Abstract

OBJECTIVE:

We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women.

STUDY DESIGN:

In a multicenter randomized controlled trial, women were stratified by the risk status and assigned to daily treatment (1 g vitamin C and 400 IU vitamin E) or placebo. The primary outcome was GH and its adverse conditions.

RESULTS:

Of the 2647 women randomized, 2363 were included in the analysis. There was no difference in the risk of GH and its adverse conditions between groups (relative risk, 0.99; 95% confidence interval, 0.78-1.26). However, vitamins C and E increased the risk of fetal loss or perinatal death (nonprespecified) as well as preterm prelabor rupture of membranes.

CONCLUSION:

Vitamin C and E supplementation did not reduce the rate of preeclampsia or GH, but increased the risk of fetal loss or perinatal death and preterm prelabor rupture of membranes.

PMID:
20207239
DOI:
10.1016/j.ajog.2010.01.050
[Indexed for MEDLINE]

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