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Exp Parasitol. 2010 Nov;126(3):389-96. doi: 10.1016/j.exppara.2010.02.010. Epub 2010 Mar 3.

Role of chemokines in regulation of immunity against leishmaniasis.

Author information

1
Department of Pathology, The Ohio State University Medical Center, 1645 Neil Avenue, Columbus, OH 43210, USA.

Abstract

Successful immunity to Leishmania depends on recruitment of appropriate immune effector cells to the site of infection and chemokines play a crucial role in the process. At the same time, Leishmania parasites possess the ability to modify the chemokine profiles of their host thereby facilitating establishment of progressive infection. Therapeutic and prophylactic strategies targeted at chemokines and their receptors provide a promising area for further research. This review highlights our current knowledge concerning the role of chemokines and their receptors in modulating leishmaniasis in both clinical settings and experimental disease models.

PMID:
20206625
PMCID:
PMC3661772
DOI:
10.1016/j.exppara.2010.02.010
[Indexed for MEDLINE]
Free PMC Article

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