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Mini Rev Med Chem. 2009 Nov 1;9(13):1538-46.

Altered hyaluronan biosynthesis and cancer progression: an immunological perspective.

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Gene Therapy Laboratory, School of Medicine, Austral University, Avenida Presidente PerĂ³n 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.


Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions, Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.

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