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Org Biomol Chem. 2010 Mar 21;8(6):1351-60. doi: 10.1039/b920535g. Epub 2010 Jan 22.

Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N-->S acyl transfer.

Author information

1
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.

Abstract

Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.

PMID:
20204207
DOI:
10.1039/b920535g
[Indexed for MEDLINE]

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