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J Biomed Biotechnol. 2010;2010:357106. doi: 10.1155/2010/357106. Epub 2010 Feb 24.

Modulation of dendritic cell responses by parasites: a common strategy to survive.

Author information

1
Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), 54090 Tlalnepantla, Estado de México, Mexico.

Abstract

Parasitic infections are one of the most important causes of morbidity and mortality in our planet and the immune responses triggered by these organisms are critical to determine their outcome. Dendritic cells are key elements for the development of immunity against parasites; they control the responses required to eliminate these pathogens while maintaining host homeostasis. However, there is evidence showing that parasites can influence and regulate dendritic cell function in order to promote a more permissive environment for their survival. In this review we will focus on the strategies protozoan and helminth parasites have developed to interfere with dendritic cell activities as well as in the possible mechanisms involved.

PMID:
20204070
PMCID:
PMC2829630
DOI:
10.1155/2010/357106
[Indexed for MEDLINE]
Free PMC Article

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