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Neuroimmunomodulation. 2010;17(4):223-8. doi: 10.1159/000290038. Epub 2010 Mar 5.

Link between interleukin-10 level and outcome after ischemic stroke.

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1
Division of Basic Medical Science, Department of Nursing, Meiho Institute of Technology, Ping Tung, Taiwan, ROC.

Abstract

OBJECTIVES:

The prognostic value of interleukin (IL)-10 in patients after acute ischemic stroke (IS) is not well understood. This study tested the hypothesis that serum levels of IL-10 are substantially increased after IS and predictive of IS outcome.

METHODS:

Serum IL-10 levels were examined 48 h after acute IS in 135 consecutive patients, and in 20 healthy and 30 at-risk controls.

RESULTS:

Mean serum IL-10 was significantly higher in IS patients than in both control groups (p < 0.0001, respectively). Additionally, serum IL-10 was significantly higher in patients with severe neurological impairment [defined as a score >or=12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe neurological impairment (NIHSS score <12) 48 h after IS (p < 0.0001). Furthermore, higher serum IL-10 was strongly and independently correlated with severe neurological impairment (NIHSS >or=12) 48 h after acute IS (p < 0.0001), and independently predictive of combined major adverse clinical outcomes (defined as recurrent IS, any cause of death or NIHSS >or=12) on day 90 following IS (p < 0.0001).

CONCLUSIONS:

Serum IL-10 is an independent prognosticator of IS outcome.

PMID:
20203528
DOI:
10.1159/000290038
[Indexed for MEDLINE]
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