Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2010 Apr 1;20(7):2163-7. doi: 10.1016/j.bmcl.2010.02.044. Epub 2010 Feb 13.

Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors.

Author information

1
Worldwide Medicinal Chemistry, Pfizer Global Research and Development, CN 8000, Princeton, NJ 08543, USA. donnela@wyeth.com

Abstract

Substituted pyridazino[4,5-b]indolizines were identified as potent and selective PDE4B inhibitors. We describe the structure-activity relationships generated around an HTS hit that led to a series of compounds with low nanomolar affinity for PDE4B and high selectivity over the PDE4D subtype.

PMID:
20202838
DOI:
10.1016/j.bmcl.2010.02.044
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center