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Rheum Dis Clin North Am. 2010 Feb;36(1):187-201, x-xi. doi: 10.1016/j.rdc.2009.12.007.

Glutamate receptor biology and its clinical significance in neuropsychiatric systemic lupus erythematosus.

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1
Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.

Abstract

The recent appreciation that a subset of anti-DNA antibodies cross-reacts with the N-methyl-d-aspartate receptor encourages a renewed examination of antibrain reactivity in systemic lupus erythematosus (SLE) autoantibodies. Moreover, investigations of their autospecificity present a paradigm for studies of antibrain reactivity and show that (1) serum antibodies access brain tissue only after a compromise of blood-brain barrier integrity, (2) the same antibodies have differential effects on brain function depending on the region of brain exposed to the antibodies, and (3) insults to the blood-brain barrier are regional rather than diffuse. These studies suggest that an anatomic classification scheme for neuropsychiatric SLE may facilitate research on etiopathogenesis and the design of clinical trials.

PMID:
20202599
PMCID:
PMC2837540
DOI:
10.1016/j.rdc.2009.12.007
[Indexed for MEDLINE]
Free PMC Article
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