Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2010 Feb;1188:103-10. doi: 10.1111/j.1749-6632.2009.05089.x.

The role of mechanical forces in the torsional component of cardiac looping.

Author information

  • 1Department of Biomedical Engineering, Washington University, St. Louis, Missouri 63130, USA. lat@wustl.edu

Abstract

During early development, the initially straight heart tube (HT) bends and twists (loops) into a curved tube to lay out the basic plan of the mature heart. The physical mechanisms that drive and regulate looping are not yet completely understood. This paper reviews our recent studies of the mechanics of cardiac torsion during the first phase of looping (c-looping). Experiments and computational modeling show that torsion is primarily caused by forces exerted on the HT by the primitive atria and the splanchnopleure, a membrane that presses against the ventral surface of the heart. Experimental and numerical results are described and integrated to propose a hypothesis for cardiac torsion, and key aspects of our hypothesis are tested using experiments that perturb normal looping. For each perturbation, the models predict the correct qualitative response. These studies provide new insight into the mechanisms that drive and regulate cardiac looping.

PMID:
20201892
PMCID:
PMC2837544
DOI:
10.1111/j.1749-6632.2009.05089.x
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center