Format

Send to

Choose Destination
Eur J Immunol. 2010 Apr;40(4):949-54. doi: 10.1002/eji.200940234.

Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.

Author information

1
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8(+) T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8(+) T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8(+) T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule-1 downregulation on CD8(+) T cells aggravates the impairment of CTL effector function in chronic HIV-1 infection.

PMID:
20201043
PMCID:
PMC3031090
DOI:
10.1002/eji.200940234
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center