Format

Send to

Choose Destination
Eur J Immunol. 2010 Mar;40(3):616-9. doi: 10.1002/eji.200940168.

Signaling by ROS drives inflammasome activation.

Author information

1
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. fmartino@hsph.harvard.edu

Abstract

Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.

PMID:
20201014
DOI:
10.1002/eji.200940168
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center