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Nat Rev Cancer. 2010 Apr;10(4):293-301. doi: 10.1038/nrc2812. Epub 2010 Mar 4.

PARP inhibition: PARP1 and beyond.

Author information

1
Laval University Medical Research Center, Laval University, Qu├ębec, Canada.

Abstract

Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

PMID:
20200537
PMCID:
PMC2910902
DOI:
10.1038/nrc2812
[Indexed for MEDLINE]
Free PMC Article

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