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J Leukoc Biol. 2010 Jun;87(6):1001-9. doi: 10.1189/jlb.0809542. Epub 2010 Mar 3.

Leukocyte function in the aging immune system.

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  • 1Division of Geriatric Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Aging is associated with a progressive dysregulation of immune responses. Whether these changes are solely responsible for the observed increased mortality and morbidity amongst the elderly is uncertain. Recent advances have highlighted the age-associated changes that occur beyond T and B lymphocytes. Additionally, multiple human and animal studies have identified a relationship between chronic low-grade inflammation and geriatric syndromes, such as frailty, suggesting that the phenomenon of "inflamm-aging" may provide a rationale for the increased vulnerability to chronic inflammatory diseases in older adults. In the present review, we broadly summarize our current understanding of age-dependent changes in leukocyte function and their contribution to aging-related disease processes.

PMID:
20200405
PMCID:
PMC4057658
DOI:
10.1189/jlb.0809542
[PubMed - indexed for MEDLINE]
Free PMC Article
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