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Diabetes Care. 2010 May;33(5):1028-30. doi: 10.2337/dc09-1961. Epub 2010 Mar 3.

Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes.

Author information

1
Department of Endocrinology, Phoenix VA Health Care System, Phoenix, Arizona, USA. peter.reaven@med.va.gov

Abstract

OBJECTIVE:

Endothelial dysfunction is frequently present in individuals with insulin resistance or type 2 diabetes and can be induced by high-fat or high-carbohydrate meals. Because exenatide reduces postprandial glucose and lipid excursions, we hypothesized that it may also improve postprandial endothelial function.

RESEARCH DESIGN AND METHODS:

In a double-blinded randomized crossover design, postprandial endothelial function was examined in 28 individuals with impaired glucose tolerance or recent-onset type 2 diabetes after a single injection of exenatide or placebo given just before a high-fat meal. Endothelial function was determined with peripheral arterial tonometry pre- and postprandially.

RESULTS:

Postprandial endothelial function was higher after exenatide compared with placebo (P = 0.0002). In the placebo phase, postprandial change in endothelial function was inversely associated with mean postprandial concentrations of triglycerides (r = -0.62, P = 0.0004). Changes in postprandial triglyceride concentrations explained 64% of exenatide's effect on postprandial endothelial function.

CONCLUSIONS:

Exenatide ameliorates postprandial endothelial dysfunction after a high-fat meal.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00974272.

PMID:
20200309
PMCID:
PMC2858168
DOI:
10.2337/dc09-1961
[Indexed for MEDLINE]
Free PMC Article

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