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Asia Pac J Clin Nutr. 2010;19(1):124-30.

Nuts, inflammation and insulin resistance.

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Human Nutrition Unit, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Spain.


The beneficial effects of nut consumption on cardiovascular disease (CVD) have been widely documented. These protective effects are mainly attributed to the role of nuts in the metabolism of lipids and lipoproteins. As chronic inflammation is a key early stage in the atherosclerotic process that predicts future CVD events and is closely related to the pathogenesis of insulin resistance, many recent studies have focused on the potential effect of nut consumption on inflammation and insulin resistance. Through different mechanisms, some components of nuts such as magnesium, fiber, alpha-linolenic acid, L-arginine, antioxidants and MUFA may protect against inflammation and insulin resistance. This review evaluates the epidemiologic and experimental evidence in humans demonstrating an association between nut consumption and these two emergent cardio-protective mechanisms.

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