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J Pediatr. 1991 May;118(5):807-11.

Randomized trial of salbutamol in acute bronchiolitis.

Author information

1
Department of Pediatrics, University of Ottawa School of Medicine, Ontario, Canada.

Erratum in

  • J Pediatr 1991 Dec;119(6):1010.

Abstract

To test whether nebulized salbutamol (albuterol) is safe and efficacious for the treatment of young children with acute bronchiolitis, we enrolled 83 children (median age 6 months, range 1 to 21 months) in a randomized, double-blind clinical trial. Participants received two treatments at 30-minute intervals of either nebulized salbutamol (0.10 mg/kg in 2 ml 0.9% saline solution) or a similar volume of 0.9% saline solution placebo. Outcome measures were the respiratory rate, pulse oximetry, and a clinical score based on the degree of wheezing and retractions. Patients in the salbutamol arm had significantly greater improvement in clinical scores after the initial treatment (p = 0.04). There was no difference between the groups in oxygen saturation (p = 0.74); patients treated with salbutamol had a small increase in heart rate after two treatments (159 +/- 16 vs 151 +/- 16; p = 0.03). We conclude that salbutamol is safe and effective for the initial treatment of young children with acute bronchiolitis.

PMID:
2019938
DOI:
10.1016/s0022-3476(05)80051-4
[Indexed for MEDLINE]

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