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Mol Biol (Mosk). 2010 Jan-Feb;44(1):140-51.

[Attenuation regulation of amino acid and amino acyl-tRNA biosynthetic operons in bacteria: comparative genomics analysis].

[Article in Russian]

Abstract

We performed a large-scale search for attenuation regulation in bacteria based on two original computer programs modeling attenuation regulation and multiple alignment along a phylogenetic tree. The programs are available from http://lab6.iitp.ru. Candidate attenuations are predicted in many bacteria from alpha-, beta-, gamma-, delta-proteobacteria, Actinobacteria, Bacteroidetes/Chlorobi, Firmicutes and Thermotogae; in Cloroflexi--upstream genes hisG, hisZ, hisS, pheA, pheST, trpEG, trpA, trpB, trpE, trpS, thrA, thrS, leuA, leuS, ilvB, ilvI, ilvA, ilvC, ilvD, ilvG. Other bacterial taxa were not predicted to have attenuation; searches were conducted across all bacterial genomes contained in GenBank, NCBI. Evolution of attenuation is discussed.

PMID:
20198868
DOI:
10.1134/s0026893310010176
[Indexed for MEDLINE]

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